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At higher concentrations (10100 M), curcumin suppresses EGFR tyrosine kinase activity, blocking downstream phosphoinositide 3-Kinase (PI3K)/AKT survival signaling in melanoma cells (Manica et al., 2023)

The antibody-ASA (AASA) was subsequently computed using a large probe radius comparable in size to the recognition domain of an antibody, allowing surface points available for protein-protein contacts, such as antibody-antigen 18 to be identified

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