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To identify the target that mediates this effect, we applied thermal proteome profiling (TPP) and uncovered the disulfide reductases GSR and TXNRD1 as LCS3 targets

More recent studies further extend its protective profile by demonstrating that salidroside limits regulated cell death pathways, including ferroptosis, pyroptosis, and PANoptosis, through coordinated regulation of PI3K/AKT, Nrf2-dependent antioxidant signaling, and hypoxia-responsive pathways, thereby preserving tubular and microvascular integrity in ischemic, septic, and crystal-associated AKI models (Tang et al

MOTS-C is a mitochondrial-derived peptide extensively studied in metabolic regulation, cellular energy signaling, and performance-focused research environments

Some particles may enter normal myometrial tissue, causing transient lack of oxygen, but dormant vessels are then recruited to keep normal uterus alive