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Other research has focused on genetic and biochemical factors

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TMAO's Impact on AS In recent years, TMAO has been found to be associated with heart failure (37), chronic kidney disease (38, 39), tumors, obesity (40), diabetes (41), and other diseases

The above claims have not been evaluated by the Food and Drug Administration

Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue

TMAO up-regulates NOX2, increasing fibronectin, p65, and Snail, which blocks the G2/M cell cycle and heightens kidney inflammation via the NOX/ROS pathway