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Patients with IC also have decreased levels of heparin-binding epidermal growth factor [8]

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Following the retrobulbar application of L-NAME, the retinal ischemia and definitively debilitated function occurred as an immediate and direct consequence of its inhibition

Furthermore, the impact of endothelial cell senescence is not limited to the vascular system

Although DCE MRI can detect subtle changes in BBB permeability in well-controlled cohorts, differences in scanning equipment, parameters, and data processing between data collection sites can dilute these relatively small changes associated with AD and aging, which are typically one order of magnitude lower than the more robust changes of other disorders like ischemic stroke (Heye et al., 2014

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