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Mice (n = 12) were randomly distributed into 4 treatment groups: vehicle (PBS 1X with 1% NaOH), arsenic trioxide (ATO

doi: 10.1186/s40842-018-0060-9 111 Leidig-BrucknerGGrobholzSBrucknerTScheidt-NaveCNawrothPSchneiderJG

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CBS cystathionine-beta-synthetase the methionine remethylation step can be facilitated by several intermediates such as the well known reaction mediated by folic acid and its active metabolites to form 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylenetetrahydrofolate reductase (MTHFR)