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Differences within FOXO proteins, like the presence or absence of specific amino acids can determine the pattern of PTMs and therefore alter the affinity to different binding partners, defining the subset of FOXO target genes regulated by the isoform

The peptide demonstrates context-dependent nitric oxide regulation, maintaining homeostasis in healthy tissue while supporting appropriate inflammatory responses during active healing

Pickart, L., J.M

This led to GHK initially being classified as a liver cell growth factor

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