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Dourado et al, 2013)

Epigenetic regulation of lipid metabolism Rapidly proliferating tumor cells require large amounts of lipids to make cell membrane and signaling lipids, and thus have hyperactive lipogenesis through the activation of genes such as FASN, which utilizes acetyl-CoA as a substrate [96]

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The result is an "energy crisis." In chronic cases, neurons enter a state of metabolic depression they are dormant, "idling" cells [5]

Diagnosis and management of clinical and subclinical cobalamin deficiencies