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The presence of oxidative stress markers and ferroptosis-related damage in placental tissues further supports the involvement of ferroptosis in RM pathophysiology (Xie et al., 2024)

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These include severe or persistent muscle pain, weakness, swelling, or symptoms suggestive of rhabdomyolysis, a rare but serious condition involving muscle breakdown

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The results from the 500-yr climate model simulation support the unusual nature of these recent trends: only 2.9% of the 13-yr TX10d trends from the climate model are larger than the observed 20022014 trend with the long-term linear trend removed (dashed blue line of Fig