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Description

The compounds bind to entirely different receptors (beta-3 adrenergic vs GLP-1/GIP)

Neural tube defects can lead to partial paralysis and anencephaly (skull and brain are underdeveloped) which is a fatal condition (8) (9)

The MCHR1 antagonist GW-856464 also entered Phase I studies in 2004

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Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ

Elevated insulin causes an increase of free serum IGF-1, nevertheless, as resistance to insulin progresses, the liver becomes insensitive to insulin-mediated suppression of IGFBP-1 [254, 256]