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However, larger randomized controlled trials have produced mixed findings, with some reporting no significant cognitive or functional benefit compared with placebo, emphasizing the need for optimized dosing strategies, longer follow-up, and biomarker-guided study designs ( Beyond BBB-bypass strategies such as intranasal delivery, major regulatory milestones in AD have been achieved with anti-amyloid monoclonal antibodies

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While this can lead to faster fading of dark spots , it also comes with higher risks: Skin irritation and redness Burning or stinging sensation Increased sun sensitivity Risk of rebound hyperpigmentation Potential long-term complications if misused This is why dermatologists strictly control how long and how often hydroquinone should be used