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Proof of this comes from observations that PKC inhibition with RBX enhances insulin action through phosphorylation of insulin- receptor substrate 1 (IRS1), Akt, eNOS, and GSK3 in STZ-DM and Zucker fatty insulin-resistant rats (73)

7.1.1 Reprogramming macrophages: probiotics and phagocytic polarization As essential components of the innate immune system, macrophages defend the host by phagocytosing and destroying pathogenic microorganisms, including bacteria, viruses, and fungi (220)