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Description

While gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS, glutamate is the primary excitatory neurotransmitter in the CNS

Dibenzocyclooctadiene lignans from the stems of Schisandra sphaerandra

& Buwalda, B

In the axonal loss, which is considered to be the main cause of permanent clinical disability in MS, key elements are inflammation, mitochondrial alteration, upregulation of sodium channels and glutamate excitotoxicity