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Vitamin B12 is generally considered safe

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To minimize the risk of side effects and interactions, its recommended to follow the recommended dosages and consult with a healthcare provider before taking any supplements, especially if you have a history of severe deficiencies or are taking other supplements or medications

You can, but it is generally not considered necessary

Direct Dosage: A single B12 injection often delivers a much higher dose directly into the system than a typical daily oral tablet, particularly when considering the limited absorption rate of the latter, contributing to their perceived and actual strength. However, for individuals with mild dietary deficiencies and no underlying absorption problems, high-dose oral B12 supplements (e.g., 1000-2000mcg daily) can sometimes overcome the need for intrinsic factor by allowing for a small amount of passive absorption, eventually raising levels, though this method is less predictable and slower than direct injection

Timing your injection on a consistent day each week and pairing the protocol with adequate protein intake (80 to 100g daily), proper hydration (64 to 80 ounces of water), and small frequent meals dramatically improves both results and tolerability