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Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, et al

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

108,109 The clioquinol derivative PBT2 has been shown to inhibit Cu-induced A accumulation and possess greater BBB permeability and solubility

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As you can see, a deficiency of glutathione would create a build-up for ROS as Polonikov describes