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This highlights the importance of miR-15/16/195/424/497 cluster also in the context of CRC besides pituitary adenoma and osteosarcoma, which were previously described

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ROS may be present in excess compared to the antioxidant capability in pathogenic situations

N-Acetyl Cysteine may interfere with chloroquine's antimalarial effects

Glossary AIDs autoimmune diseases RA rheumatoid arthritis SLE systemic lupus erythematosus MS multiple sclerosis DM dermatomyositis HIF hypoxia-inducible factor PGK phosphoglycerate kinase LDHA lactate dehydrogenase A pVHL the tumor suppressor protein Von Hippel-Lindau Tumor Suppressor Protein VEGF vascular endothelial growth factor ODD oxygen-dependent degradation domain PHDs prolyl hydroxylases Ub ubiquitin proteins FIH factor-inhibiting HIF TAD transactivation domain HREs hypoxic response elements GLUT1 glucose transporter 1 EPO erythropoietin MAPK mitogen-activation protein kinase ERK extracellular protein kinases EGF epidermal growth factor IGF-1 insulin-like growth factor-1;PI3K, phosphoinositide 3-kinase PKB/AKT protein kinase B mTOR the mechanistic target of rapamycin kinase STAT3 signal transducer and activator of transcription 3 AMPK AMP-activated protein kinase JAK Janus tyrosine kinase NLRP3 nucleotide-binding oligomerization structure-like receptor family pyrin domain protein 3 Treg regulatory T cells TNF- tumor necrosis factor TAK1 transforming growth factor-activated kinase 1 HMGB1 hypoxia-induced high mobility group proteins 1 JNK c-Jun N-terminal kinase SIRT silence information regulator Ang1 angiopoietins1 PDGF-BB platelet-derived growth factor-BB IL-1 interleukin-1 ROS reactive oxygen species NF-B nuclear factor kappa-B GRK2 G protein-coupled receptor kinase 2 PDK1 phosphoinositide-dependent protein kinase-1 ATP adenosine triphosphate NETs neutrophil extracellular traps GM-CSF granulocyte-macrophage colony stimulating factor BLyS B-lymphocyte stimulator DMARDs disease-modifying anti-rheumatic drugs LPS lipopolysaccharide SS Sjgrens syndrome LncRNA Dpf3 long non-coding ribonucleic acid Dpf3 microRNA micro-ribonucleic acid RORt RAR-related orphan receptor gamma t MDSCs myeloid-derived suppressor cells SPNTi sono-activatable semiconducting polymer nanopartners SDT sonodynamic therapy TPZ tirapazamine ICD immunogenic cell death MLS macrophage-like synoviocytes FLS fibroblast-like synoviocytes CIA collagen-induced arthritis model OA osteoarthritis EndoMT endothelial-to-mesenchymal transition CXCL12 chemokine (C-X-C motif) ligand 12 OCs osteoclasts ANGPTL4 angiopoietin-like 4 OBs osteoblasts RANKL receptor activator of NF-B ligand MMP2 matrix metalloproteinase 2 DEX Dexamethasone ART artesunate RBA roburic acid RIPK3 receptor-interacting protein kinase 3 IECs intestinal epithelial cells LN lupus nephritis PLN proliferative lupus nephritis mtROS mitochondrial ROS RET reverse electron transfer mTORC1 mTOR complex 1 MRL/lpr mice metabolic reprogramming in lupus-prone mice ECM extracellular matrix TGF- transforming growth factor- jDM juvenile DM RIG-I retinoic acid-inducible gene I HLA-B27 human leukocyte antigen-B27 HBOT hyperbaric oxygen therapy PIGF placental growth factor SDF-1 stromal cell-derived factor-1 S1P sphingosine-1-phosphate MAN -mangostin iNOS inducible nitric oxide synthase AIA antigen-induced arthritis FKBP12 FK506 binding protein 12 ITP immune thrombocytopenia NAC N-acetylcysteine GSH glutathione GSSG oxidized glutathione disulfide TAC the total antioxidant capacity NRF-2 NF-E2-related factor-2 KEAP-1 kelch-like ECH-associated protein 1 HO-1 heme oxygenase 1 EVOO extra virgin olive oil AP1 activator protein-1 DNA deoxyribonucleic acid LDH lactate dehydrogenase NDUFA4L2 NADH dehydrogenase (ubiquinone)-1 EAE experimental autoimmune encephalomyelitis

Physiological and biochemical dissection reveals a trade-off between antioxidant capacity and heat tolerance in bread wheat ( Triticum aestivum L.)