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The induction process is triggered by the activation of signaling pathways which are dependent on specific nuclear transcription factors

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: Alterations of mononuclear inflammatory cells, CD4/CD8+ T cells, interleukin 1beta, and tumour necrosis factor alpha in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis

Oxidative stress is critical for the development of these diseases