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But it is known that prolonged exposure to oxidative stress can damage cellular components (proteins, lipids and DNA) [13], contribute to cellular aging [14], and play an important role in the pathogenesis of cancer, atherosclerosis, Parkinson, Alzheimers and various chronic diseases such as diabetes mellitus and its complications [15, 16, 17, 18, 19, 20]

More BH4 depletion causes more uncoupling

DOI:10.3390/ijms19071987

Ko WC, Lei CB, Lin YL, Chen CF

The high state in PMW is seen after excessive withdrawal of systemic estrogenic hormones, which deeply affects the physiological process and disrupts the gut milieu and integrity (244)

However, they did not study the variation of microbial functions, which might be crucial for understanding treatment processes more comprehensively