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Placebo effects, expectation bias, and individual variability all confound interpretation

Several small-molecule chaperones, such as amiloride [151], AT2101 (isofagomine) [152] and histone deacetylase inhibitors [153], have been shown to increase GCase activity and reduce oxidative stress in PD fibroblasts carrying GBA1 mutations or enhance GCase activity in GBA macrophage models

The researchers found that apart from increasing GH and IGF-1, sermorelin uniquely prompted both FSH and LH release [38]

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Denny, John T., Sagar S

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