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We will demonstrate in the following paragraph that carbohydrates in tobacco represent a far more important source of smoke-borne acrolein

These products are formed through the interaction of ROS with lipids, leading to cell membrane damage, protein modification, and DNA injury, thereby accelerating disease progression [129]

The stronger structural distortion seen in our MD simulation as compared to our CD results could thus be contributed by multiple factors

Stockwell and others officially introduced the concept of ferroptosis to describe the iron-dependent cell death driven by lipid peroxidation on the plasma membranes of cells ( Ferroptosis differs from other forms of cell death, such as apoptosis, necroptosis, pyroptosis, and autophagy

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Finally, apoptosis was analyzed to determine whether the inactivation of GSTA4 induced apoptosis