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In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]

Furey, A., Moriarty, M., Bane, V., Kinsella, B

Torne, C

Effects of l-carnitine supplementation on inflammatory factors and malondialdehyde in patients with nonalcoholic steatohepatitis (NASH)

Male Wistar rats were divided into five groups: one control (untreated) and four NiCl 2 -treated groups, each receiving single oral dose of NiCl 2 at 45, 90, 135, and 180 mg/kg body weight