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Opened: A Critical Distinction This is where a lot of the confusion comes from

Once FTPP binds to this receptor complex, the proapoptotic domain gets internalized into the endothelial cell

In comparison to traditional PSs, activatable PSs (aPSs) can be considered as PDT prodrugs, which remain inactive and non-toxic in their OFF state but transition to an ON state in response to specific stimuli present in the tumor microenvironment 30,31,32,33,34