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For example, aztreonam and ceftazidime have identical R1 side-chains and are cross-allergic (despite belonging to different classes of beta-lactams)

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Its gentle, effective, and has decades of clinical data behind it

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This is what Kennedy has called the war on peptides. In explaining its decisions, the FDA pointed to well-established research in peptide drug development that injectable peptides carry the risk of causing immune reactions

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Some clinicians prefer to avoid the DAC version specifically because pulsatile release is more physiological

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Extended Half-Life and Sustained Receptor Engagement The 13-amino acid N-terminal extension and Arg3 substitution reduce IGFBP binding by 7080%, extending the effective half-life from approximately 10 minutes to 2030 hours in rodent plasma resulting in prolonged IGF-1R activation in cell culture and animal models that is not achievable with native IGF-1 or shorter analogues

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transient impairment of glucose tolerance is possible, particularly in individuals with pre-existing insulin resistance Injection site reactions: Mild and typically localised Contraindications include active malignancy (GH-IGF-1 signalling can promote tumour growth), pituitary-dependent conditions, pregnancy, and active diabetic retinopathy

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