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Peralta CA, Katz R, Sarnak MJ, Ix J, Fried LF, De Boer I, et al

Neuropeptide Y (NPY) Inhibitors The ARC NPY neurons inhibit the anorexigenic POMC neurons (via NPY Y1 and Y5 receptors) and promote the release of the orexigenic neuropeptides orexin and MCH in the LHA, thus promoting food intake

Normal opioid tone and hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome despite marked functional impairment

The goal is to keep the plasma concentration within the desired therapeutic window for as much of the 24-hour cycle as possible

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