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Based on the calcium dependence of calcineurin (CaN), calcium further serves as a second messenger to drive the CaN/nuclear factor of activated T cells (NFAT) pathway, participating in osteoblast proliferation, differentiation, and apoptosis (96)

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Protein ratios (normalized to GAPDH) were used to quantify fold change relative to control and are shown in a plot graph below each blot

Tamoxifen induces apoptosis in P-gp expressing cells To determine if tamoxifen-induced collateral sensitivity of drug resistant cells is due to enhanced apoptosis, AuxB1 and CHO R C5 cells were treated with tamoxifen for 24 h and then examined for the presence of apoptotic cells using FITC-conjugated annexin-V and cell staining with Hoechst Dye

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