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10.1016/j.freeradbiomed.2008.12.018 243

Mechanistically, BL-mediated protection involves downregulation of IFN- production, attenuation of cytotoxic microglial activation and CD4 + T cell responses, expansion of Treg populations, and suppression of Th17 cell differentiation

check IGF-1 at 6 weeks | | Clonidine | Alpha-2 suppression of SRIH | Potentiates GH response | Check IGF-1 at 6 weeks | | Levothyroxine (hypothyroid replacement) | Restores permissive thyroid tone | Normalises somatotroph response | Achieve euthyroid first | | GLP-1 agonists | Weight/fat reduction lowers SRIH tone | May potentiate GH response | Re-evaluate dose at 12 weeks | Special Populations and Interaction Considerations Paediatric GHD Walker et al

-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

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Mutations and DNA damage may also be caused by oxidative changes to DNA sugar-phosphate backbones, which can be induced by O 2 - generating enzymes like NADPH oxidase and mitochondria