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442 Research into ketamine actions in the CNS revealed multiple effects, including potentiation of synaptogenesis, increased density of dendritic spines and upregulation of postsynaptic levels of AMPA receptors

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Additionally, impaired mitochondria disrupt cellular processes such as apoptosis and autophagy, further contributing to neuronal loss and pathology in these diseases ( 2.3 Oxidative stress Oxidative stress is another important process that occurs in neurodegeneration