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Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

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GSH reduces the oxidized catalytic cysteine (Cys47-SOH) of PRDX6, sustaining its peroxidase activity against lipid peroxides, like GPX4, and linking PRDX6 directly to ferroptosis resistance (Fig

Its also needed for fatty acid metabolism and amino acid metabolism , which are key for energy and healthy tissues

Different blood samples from the same normal control donor were processed on three different days at three concentrations 0.4, 0.6, and 0.8 mM tBOOH