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Although several antiproliferative agents are already available for the treatment of fibroids, in the future ECM should be considered as a crucial target

This suggests that adipocyte-derived factors in the adipocyte secretome may enhance EV biogenesis in cancer cells, potentially amplifying reciprocal communication between tumor cells and adipocytes

The superiority of HFR with respect to OL-HDF has also been proven in some studies, where a significant decrease in most of the inflammatory and oxidative stress parameters is objectified.45 In conclusion, in most of the published studies (Table 3) the switch from HD to HFR led to an improvement in inflammation with a significant decrease in serum levels of CRP, IL-6, IL-1 and TNF and a significant increase in albumin and prealbumin

83 MatsumotoT.TatedaK.MiyazakiS.FuruyaN.OhnoA.IshiiY.et al (1999)

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doi: 10.1016/j.foodres.2018.08.045 107