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For example, if you are treating a patient with the antiCTLA-4 antibody ipilimumab, you see more colitis

Lu, Y., Yeung, N., Sieracki, N

Navalpakam A, Thanaputkaiporn N, Poowuttikul P (2022) Management of anaphylaxis

Indeed, optimizing the use of bacterial inoculation with biochar might be employed as an auspicious and valuable tactic to alleviate the detrimental effects of water scarcity on agricultural plants supporting agronomic yield, growth, production, and other physiological and water-related characteristics

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This requires more strategic dosing to avoid exaggerated side effects and also more strategic discontinuation protocols to avoid exaggerated withdrawal symptoms