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Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes

Acta Pharmacol Sin (2022) 43(8):1889904

The Asp 2 analog, which had not been evaluated in the earlier studies, also exhibited pronounced inhibitory activity

The most recent clinical trial candidate showing promise is ursodeoxycholic acid (UDCA), a drug often used in chronic inflammatory liver disease with an extensive safety profile (Sathe et al., 2020)