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doi: 10.1016/j.cell.2021.12.024 231 FrankDVinceJE

Other indirect ways to stimulate the antiepileptic effects of KD may lay in the alterations of the metabolism of neurotransmitters such as glutamate and gamma-amino butyric acid (GABA), and the activation of energy-sensing signaling pathways such as the PPAR, mammalian target of rapamycin (mTOR), and adenosine monophosphate-(AMP)-activated kinase (AMPK) pathways (71, 72)

mHTT affects mitochondrial complex activation and dysfunction of the mitochondrial respiratory chain in skeletal muscle, which may be markers of HD progression

Amino acid sensing in the gastrointestinal tract

Twelve patients received a daily dose of 100 mg/kg and 1 patient received a daily dose of 200 mg/kg

Johns County, and all of Northeast Florida