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It is worth noting that in yeast SF3B1 lacks an IDR, and CDK11 is absent 20 , however a SNIP1 yeast homolog, Pml1p, contains an FHA domain 117

discovered the transcription factor HIF associated with hypoxic stress under low-oxygen conditions ( Figure 1 )

56 PNPLA3 I148M variant has limited hydrolase activity, therefore halts retinyl ester release, and finally accumulating of TGs and retinyl esters in the hepatocytes and stellate cells, leading to fatty liver