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One of the key regulators of this response is the transcription factor hypoxia-inducible factor (HIF) (55)

doi: 10.1016/j.anifeedsci.2021.114891 217

However, there is an increasing need for animal models of depression other than the currently available models of behavioural despair (forced swim test and tail suspension test)

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However, Ssu72 is restored within a knockout genetic background rather than introduced as an independent intervention

However, the success of this treatment in solid tumors has been challenged by the tumor-antigen heterogeneity, impaired CAR-T cell trafficking and infiltration, and the presence of an immunosuppressive tumor microenvironment (TME) [6]