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First, it highlights the unique role of COFs in reversing the immunosuppressive tumor microenvironment-through intrinsic enzyme-mimicking activities (such as catalase-like or glutathione peroxidase-like functions) or by carrying functional components-to alleviate hypoxia and deplete GSH (Section 5)

Similar promoter methylation events have been described in other cancers, including the extracellular regulation genes (WIF1), Dickkopf Wnt Signaling Pathway Inhibitor (DKK1-3), SFRP1, 2, 4, and 5) and intracellular regulatory genes (DACT1-3, Axin, APC)

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Moreover, the intracellular transformation of NSBSO and the formation of nanofibers may be related to its high cytotoxicity

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Water molecules were modelled manually into clear spherical density within reasonable hydrogen bonding distance to amino-acids or other waters