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Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

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12 In the electrically stimulated contraction of guinea pig ileum model, mitragynine pseudoindoxyl is 20-fold more potent than morphine at inhibiting contractions and 100-fold more potent than mitragynine

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