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Below are three example protocols based on current community knowledge and clinical data

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During tumorigenesis, abnormal hypermethylation of the cytosine in CpG islands and hypomethylation of the whole genome result in genome instability and alterations in gene expression profile, including silencing of tumor suppressor genes, endogenous retro-elements, and tumor antigens, and activation of oncogenes (Liang and Weisenberger, 2017

After that, baseline medical assessments were conducted by a physical medicine specialist and a general physician, and each participant was assigned a medical file