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We used the WebPSN (Seeber et al., 2015

Copper ions drive the abnormal aggregation of lipoylated proteins, followed by the downregulation of Fe-S cluster protein expression, causing proteotoxic stress and, ultimately, cell death [8]

The 20 members met routinely to guide the development of a new medical school and build momentum for the big-dollar startup, which they estimated would cost about $100 million