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Mechanism focus: Instead of simply altering neurotransmitter release, Dihexa targets pathways that stimulate synaptogenesis the formation of new synaptic connections

Caton, S.J

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51 Moreover, AMPK was shown to be required for the homeostasis of TJactinmicrotubule arrangement and led to cingulin phosphorylation, which improved cingulinmicrotubule binding but reduced actin affinity to mitigate TJ permeability