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An imbalance in pro- and antioxidants, known as oxidative stress, stimulates inflammatory responses that can lead to the development and maintenance of allergic disorders (95, 96)

Mechanistically, DMF regulates the expression of factors involved in the de novo cysteine synthesis (CBS), cystine uptake (SLC7A11), and GSH generation (GCLC, GCLM) through NRF2-dependent and independent pathways

In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)

A standard curve (e.g., using ascorbic acid or Trolox) can be used to quantify the antioxidant capacity of the sample

In total, three positive selection cycles were carried out, followed by two negative selection cycles and a final positive selection

Its effects are comparable to those of paclitaxel and it can treat more tumor types