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In clinical practice, dull or uneven skin tone is often related not only to sun exposure, but also to internal factors such as: Oxidative stress Chronic stress and lack of sleep Low-grade inflammation Reduced cellular repair capacity When these factors accumulate, skin recovery slows downeven with good skincare routines

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Data availability The tumor RNA-seq data generated in this study have been deposited in the SRA database under accession code PRJNA1280553