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The initial signs and symptoms often include a lesion that is soft to palpation, usually pigmented, initially asymptomatic, with irregular borders and a color spectrum ranging from dark brown to bluish-black, occasionally presenting variations of gray, purple, and red due to ulcerations, or depigmentation (Figure 5) [39,40]

However, abnormal levels of polyamines (e.g., putrescine, spermidine, spermine, and cadaverine) are associated with colorectal cancer, in which the metabolic pathway becomes dysregulated, preventing the breakdown of polyamines, leading to their buildup and abnormal cell proliferation (161)

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Because of this, these clinically studied nutrients help combat general physical and mental fatigue

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[Perhaps they are not aware that some groups of people eating very high-meat diets, like the Inuit, had very low rates of heart disease