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The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)

Argireline is often called "topical Botox" because it targets expression lines through a different pathway

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