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however, available evidence from repeated-dose animal studies and clinical observations suggests a favorable safety margin, with no evidence of dependence, tolerance, or withdrawal phenomena (6)

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These have been shown in models of muscle injury, tendon degeneration, and experimental colitis

EBioMedicine 62:103130 Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease

34 In a similarly sized double-blind, placebo-controlled study of intravenous ketamine (0.2 mg/kg) for treatment of migraine in the emergency department setting, however, ketamine was not superior to placebo for acute pain relief and caused adverse effects of generalized discomfort at 30 minutes and fatigue at 60 minutes, although no serious adverse events occurred

Yes, and sometimes theyre even more effective together