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Ethics declarations Competing interests All the authors declared that no competing interests

Au/TF-MOF functioned as nanozymes, producing O 2 to alleviate tumor hypoxia, initiating the Fenton reaction to generate OH for CDT, and depleting intracellular glucose to achieve starvation therapy

Vitamin B12 blood levels and peripheral blood counts must be monitored initially at one month after the start of treatment with Nascobal Nasal Spray, and then at intervals of 3 to 6 months