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Furthermore, the bloodbrain barrier (BBB) significantly limits the bioavailability of these drugs, as it prevents effective doses from reaching the brain

10.1111/liv.14786 Liver Int

Chest injuries are usually accompanied by pain and difficulty breathing during coughing, deep inhalation, and lower limb movements

Dose-dependently reduced hepatic lipid droplet accumulation (Oil Red O staining) and decreased serum ALT and AST levels in db/db mice

Since AKT is frequently hyperactive in TNBC, this mechanism explains the paradox of high copper levels coexisting with cuproptosis resistance, and underscores AKT inhibition as a potent sensitizer to copper-based therapies