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However, recent studies have highlighted the dual role of angiogenesis in neurodegeneration

Shen J, Kom MC, Huang H, Fu G, Xie Y, Gao Y, Tang Y, Yan J, Jin L (2023) Role of NF-B signaling pathway in hexavalent chromium-induced hepatotoxicity

Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial

As of September 30, 2024, among 121 evaluable patients (median prior lines of therapy = 3), the objective response rate (ORR) was 42.1%, with a confirmed ORR (cORR) of 36.4% and a disease control rate (DCR) of 80.2%

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However, if their degradation or biliary excretion are impaired, LPS can reach the systemic circulation, where they bind to Toll-like receptor 4 (TLR4) on leukocytes, endothelial cells, and platelets, causing arterial inflammation