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They're more common at doses above 300 mcg and typically resolve within 48 weeks as the body adapts

If necessary, the mixture was sonicated briefly with a bath-type laboratory sonicator (VWR Model 75) at the maximum power setting (9) for 30 s at room temperature to complete dispersion

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Jarukamjorn et al

Insulin-like growth factor-I and angiographically documented coronary artery disease