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This increase in reactive oxygen species results in depletion in alveolar levels of the key antioxidant glutathione (GSH) and increases in alveolar oxidized glutathione (GSSG), a phenomenon seen both in animal models and humans who abuse alcohol

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The same research group further showed that various statins, including pravastatin, simvastatin, and Fluvastatin, improved the antimicrobial activity of INH, RIF, and PZA in THP-1 cells and the C3HeB/FeJ mouse model (140)