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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

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421 The NLRP3 inflammasome-GSDMD-caspase-1/NF-B axis represents a pivotal but context-dependent target in ROS-mediated pyroptosis, but NLRP3 has dual roles in disease pathogenesis