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For example, PHD inhibitors such as DFO can prevent HIF-1 degradation, thereby enhancing H-type vessel formation and bone repair in ischemic or bone defect models (Liu et al., 2023

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The depsipeptide romidepsin reverses HIV-1 latency in vivo

However, they also highlight a deeper, systemic challenge: ferroptosis is not a static or isolated event but a dynamic biological process intricately coupled with metabolism, redox homeostasis, and immune surveillance